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重组小鼠CD8α蛋白(Recombinant Mouse CD8α Protein) 
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型号: TL-752 规格: 100ug

重组人小鼠 CD8α蛋白(Recombinant   Mouse CD8α Protein),GMP级

产品描述(Description)

T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

分子别名(Synonym)

BB154331 Protein, Mouse; Ly-2 Protein, Mouse; Ly-35 Protein, Mouse; Ly-B Protein,Mouse; Lyt-2 Protein, Mouse

纯度(Purity)

≥95%采用 SDS-PAGE 凝胶和高效液相色谱分析

内毒素(Endotoxin)

≤0.09EU/ug

表达宿主(Expression host)

 

人 HEK293 细胞

分子量(Molecular Weight)

重组小鼠 CD8α包含 182 个氨基酸,预测理论分子量为 20.55kd

蛋白序列(Protein Sequence)

DNA序列编码小鼠CD8α(UniProtKB/Swiss-Prot: P01731)表达带有His 标签在C 末端

来源(Source)

小鼠

使用说明(Instructions)

稳定性和储存:冻干的样本的可以在 4℃保存 24 个月,溶解后的液体可以于-20℃保存 6-12 个月,并且避免反复冻融。

提纯方法(Purification Method)

层析纯化

性状(Character)

本品为白色疏松体

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