【Product Description】
Gentamicin sulfate is an aminoglycoside (aminocyclitol) antibiotic isolated from Micromonospora purpurea and represent products of secondary carbohydrate metabolism. They are a closely related group of bactericidal antibiotics and have broadly similar toxicological features.1 Gentamicin sulfate is an antimicrobial agent with bactericidal properties against Gram-negative and Gram-positive bacteria and Mycoplasma spp. Its Mode of Action (MOA) includes binding to the L-6 protein of the 50S ribosomal subunit, inhibits translocation and elicits miscoding and thereby inhibits protein synthesis and compromising the bacterial cell-wall/membrane structure causing bacterial cell death. The 2-deoxystreptamine-containing antibiotics include the structurally related neomycins and streptomycins2.
Cross-resistance occurs between Kanamycin, Neomycin, Paromomycin and Framycetin and partial cross-resistance has been reported between Kanamycin and Streptomycin. The Aminoglycosides are excellent at synergizing with the β-Lactams and glycopeptides to improve the efficiency of their bactericidal activity3. It is incompatible with Amphotericin, Penicillins, sodium bicarbonate and other drugs.
Important Note: Please consult other comprehensive pharmacology references regarding other antibiotic properties, characteristics, interactions and possible incompatibilities.
Some Predominant Characteristics include:
l Easy-To-Use-Formulation
l Bactericidal Activity
l Stable in Solution
l Sterile-Filtered
【Instructions/Procedure】
The product should be stored at -20℃~-10℃. The contents should not be left in the light for prolonged periods as it is light sensitive. When stored in the dark under ideal conditions, the product is stable until the expiry date.
1. Take a bottle out from proper storage conditions at -20℃~-10℃ ， and read the label.
2. Ensure that the cap of the bottle is tight.
3. Gently swirl the solution in the bottle.
4. Wipe the outside of the bottle with a disinfectant solution such as 70% ethanol.
5. Using aseptic/sterile technique under a laminar-flow culture hood, work according to established protocols.
6. Recommended use: 1:1000
【Precaution and Disclaimer】
For research use only, not for clinical diagnosis and treatment.
