Soluble ICAM-1/CD54, Mouse, Recombinant
Product Overview
Mouse soluble ICAM-1 is a recombinant protein derived from the cell adhesion molecule ICAM-1 (CD54). ICAM-1 has a molecular mass of approximately 95 kDa. It is a membrane protein expressed on many cell types and its expression is upregulated upon cell activation. It binds to two integrins on leukocytes, LFA-1 and Mac-1. Cell adhesion mediated by these molecules is critical for a wide range of cellular interactions in the immune system, including leukocyte adhesion to endothelial cells and interaction between T cells and antigen-presenting cells. The adhesion of leukocytes to ICAM-1 requires functional activation of LFA-1 or Mac-1 on leukocytes. Purified sICAM-1 adsorbed to a solid support binds activated cells expressing LFA-1 or Mac-1, but not resting cells. This binding can be blocked by the monoclonal anti-ICAM-1 antibody (in mouse with clone YN1/1; Catalog #01503), anti-LFA-1 or anti-Mac-1, indicating a direct interaction of these molecules in cell adhesion. Soluble ICAM is useful for the studies of the activation of leukocyte adhesion in immune responses and inflammatory reactions.
Contains:Supplied in phosphate-buffered saline
Cell Type:淋巴细胞; T细胞
Species:小鼠
Area of Interest:免疫学; 干细胞生物学
Related products
Description Catalog # Format
Mouse Striatal Neurospheres, 1 vial 00330 1 vial
Mouse Soluble ICAM, 0.5 mg 02213 0.5 Kit
Mouse Soluble ICAM, 0.1 mg 02203 0.1 mg
Mouse Neutrophil Sample Kit 19722 1 Kit
Mouse Neutrophil Sample Box 19722A 1 Box
Mouse Neutrophil Negative Selection Kit 19762 1 Kit
Mouse IgG1 Isotype Control-FITC, 100 ug 10310 0.1 mg
Mouse IgG1 Isotype Control - PE, 0.1 mg 10311 0.1 mg
Mouse Cortex Neurospheres, 1 vial 00331 1 vial
Uante,您的科研物资战略合作伙伴!
重庆市寰宇安泰生物科技有限公司