Stemcell 73174 GSA 10
Product Overview
GSA 10 is an agonist of Smoothened (SMO), a cell surface receptor and mediator of the hedgehog signaling pathway. It is a quinolinecarboxamide derivative that binds in a distinct binding pocket from cyclopamine. GSA10 is active at an EC₅₀ of 1.2 μM in an alkaline phosphatase-based mouse mesenchymal cell line (C3H10T1/2) differentiation assay (Gorojankina et al.).
DIFFERENTIATION
· Promotes differentiation of multipotent mesenchymal progenitor cells into osteoblasts (Gorojankina et al.).
CAS Number:300833-95-8
Alternative Names:Not applicable
Chemical Formula:C₂₆H₃₀N₂O₅
Molecular Weight:450.5 g/mol
Purity:≥ 95%
Pathway:Hedgehog
Target:SMO
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