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Anti-Human CD326 (EpCAM) Antibody, Clone 5E11.3.1
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Anti-Human CD326 (EpCAM) Antibody, Clone 5E11.3.1 
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2470.00
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品牌: StemCell 型号: 01422
规格: 0.1 mL

Anti-Human CD326 (EpCAM) Antibody, Clone 5E11.3.1

Mouse monoclonal antibody against human CD326 (EpCAM)

  • 产品描述
  • The 5E11.3.1 antibody reacts with the human epithelial cell adhesion molecule (EpCAM or CD326), an ~40 kDa type I transmembrane glycoprotein, which functions as a homophilic and Ca++-independent adhesion molecule. This antibody shows positive staining on luminal cells of normal human mammary epithelium. No staining to weak staining is observed within the basal cell compartment of the mammary epithelium. The 5E11.3.1 antibody gives variable staining on malignant breast epithelium. Positive staining is observed on the following cell lines: MCF7, CAMA, T47D, BT10, BT20, COLO 205, and WIDR. Staining is negative on human bone marrow cells, blood cells, lymphoid and mesenchymal tissues, and mammary and marrow fibroblast cultures. EpCAM has roles in several cellular processes, including signaling, migration, proliferation, and differentiation. It is expressed early during erythrogenesis and has been identified as a stem cell marker. The EpCAM protein is found on the basolateral membrane of most normal epithelial cells and is highly expressed in bone marrow, colon, and lung. EpCAM is not expressed on mesothelial cells or mesotheliomas, and so is widely employed as a diagnostic marker to distinguish mesothelioma and carcinoma cells, as well as serving as a target for immunotherapeutic treatment of carcinomas.
  • Components:
  • Subtype:

    Target Antigen:

    CD326 (EpCAM)

    Reactive Species:

    Conjugation:

    FITC; 未结合

    Host Species:

    小鼠

    Cell Type:

    乳腺细胞

    Application:

    细胞分离; 流式细胞术; 免疫组化

    Area of Interest:

    上皮细胞生物学; 干细胞生物学

    Clone:

    5E11.3.1

    Gene ID:

    4072

    Isotype:

    IgG1

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