Stemcell 60023 Anti-Mouse CD8a Antibody, Clone 53-6.7
Product Overview
The 53-6.7 antibody reacts with murine CD8a, a 32 - 34 kDa type I transmembrane glycoprotein which is a subunit of CD8. CD8 is a disulfide-bonded dimer, found either as a heterodimer of CD8a (α) and CD8b (β) subunits (i.e., αβ) or a homodimer (αα). CD8 acts as a co-receptor to the T cell receptor (TCR) during T cell activation by binding MHC Class I molecules presented by an antigen-presenting cell. It functions to strengthen the association between the TCR and MHC I-antigen complex and to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. The CD8a chain binds to the alpha-3 domain of class I MHC molecules. CD8 is expressed in the αβ form by a majority of thymocytes and a subset of mature peripheral blood T cells (T cytotoxic cells), and in the ββ form by γδ T cells, a subset of intestinal intraepithelial lymphocytes and dendritic cells. The 53-6.7 antibody reportedly blocks antigen presentation via MHC class I and inhibits IL-2-dependent T cell responses.
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse CD8+ T Cell Enrichment Kit (Catalog #19753) and EasySep™ Mouse CD8+ T Cell Isolation Kit (Catalog #19853).
Subtype:一抗
Target Antigen:CD8a
Reactive Species:小鼠; 蟾蜍
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合
Host Species:大鼠
Cell Type:T细胞; CD8+T细胞
Application:细胞分离; CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀
Area of Interest:免疫学
Clone:53-6.7
Gene ID:12525
Isotype:IgG2a, kappa
Related products
Description | Catalog # | Format |
Anti-Ms CD8a, 53-6.7, PS, 100µg | 60023PS | 100 µg |
Anti-Ms CD8a, 53-6.7, PS, 25µg | 60023PS.1 | 25 µg |
Anti-Ms CD8a, 53-6.7, PE, 50 | 60023PE.1 | 50 µg |
Anti-Ms CD8a, 53-6.7, PE | 60023PE | 200 µg |
Anti-Ms CD8a, 53-6.7, FI, 500µg | 60023FI | 500 µg |
Anti-Ms CD8a, 53-6.7, FI, 50µg | 60023FI.1 | 50 µg |
Anti-Ms CD8a, 53-6.7, BT, 500µg | 60023BT | 500 µg |
Anti-Ms CD8a, 53-6.7, BT, 50µg | 60023BT.1 | 50 µg |
Anti-Ms CD8a, 53-6.7, AZ, 100µg | 60023AZ | 100 µg |
Anti-Ms CD8a, 53-6.7, AZ, 25µg | 60023AZ.1 | 25 µg |
Anti-Ms CD8a, 53-6.7, AD, 25 | 60023AD.1 | 25 µg |
Anti-Ms CD8a, 53-6.7, AD | 60023AD | 100 µg |
Anti-Ms CD8a, 53-6.7 | 60023 | 500 µg |
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