Stemcell 60039AD Anti-Human CD105 Antibody, Clone 43A3
Product Overview
The 43A3 antibody reacts with CD105 (endoglin), an ~180 kDa cell surface glycoprotein which is a disulfide-bonded homodimer of ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-β receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Other ligands reportedly include Activin A, BMP-2 and BMP-7. CD105 has important roles in angiogenesis, cardiovascular development and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia.
This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411) and MesenCult™-XF Medium (Catalog #05420).
Subtype:一抗
Target Antigen:CD105（内皮糖蛋白）
Reactive Species:人; 小鼠
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合
Host Species:小鼠
Cell Type:造血干细胞和祖细胞; 间充质干细胞和祖细胞
Application:流式细胞术; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:内皮细胞生物学; 干细胞生物学
Clone:43A3
Gene ID:2022
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD105, 43A3, PE, 25 | 60039PE.1 | 25 tests |
Anti-Hu CD105, 43A3, PE | 60039PE | 100 tests |
Anti-Hu CD105, 43A3, FI, 100tests | 60039FI | 100 tests |
Anti-Hu CD105, 43A3, FI, 25tests | 60039FI.1 | 25 tests |
Anti-Hu CD105, 43A3, BT, 100µg | 60039BT | 100 µg |
Anti-Hu CD105, 43A3, AZ, 100tests | 60039AZ | 100 tests |
Anti-Hu CD105, 43A3, AZ, 25tests | 60039AZ.1 | 25 tests |
Anti-Hu CD105, 43A3, AD, 25 | 60039AD.1 | 25 tests |
Anti-Hu CD105, 43A3, AD | 60039AD | 100 tests |
Anti-Hu CD105, 43A3 | 60039 | 100 µg |
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