Stemcell 60097AZ Anti-Human CD45RO Antibody, Clone UCHL1
Product Overview
The UCHL1 antibody reacts with an extracellular epitope on CD45RO, the shortest isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5 and 6 that encode the extracellular RA, RB and RC polypeptides of CD45 gives rise to up to 8 isoforms with molecular masses of 180 - 240 kDa. Excision of all three exons generates the ~180-kDa CD45RO isoform, which is expressed on activated and memory (but not naïve) T cells, some B cell subsets, activated monocytes and macrophages, and granulocytes. CD45RO enhances both T cell receptor- and B cell receptor-mediated activation and is a known ligand for CD22 on B cells. The UCHL1 antibody has been employed to identify T-cell lymphomas and leukemia and is commonly used in combination with antibodies against CD45RA to discern memory and naïve T cells. The proportion of CD45RO+ (memory) T cells typically increases with age. The UCHL1 epitope is destroyed by treatment with neuraminidase or O-glycosidase.
Subtype:一抗
Target Antigen:CD45RO
Reactive Species:黑猩猩; 普通狨猴; 人
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合
Host Species:小鼠
Cell Type:T细胞; CD4+T细胞; CD8+T细胞
Application:细胞分离; 电子显微镜; ELISA; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学; 干细胞生物学
Clone:UCHL1
Gene ID:5788
Isotype:IgG2a, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD45RO, UCHL1, UC, 100µg | 60097 | 100 µg |
Anti-Hu CD45RO, UCHL1, PS, 100tests | 60097PS | 100 tests |
Anti-Hu CD45RO, UCHL1, PS, 25tests | 60097PS.1 | 25 tests |
Anti-Hu CD45RO, UCHL1, PE, 100tests | 60097PE | 100 tests |
Anti-Hu CD45RO, UCHL1, PE, 25tests | 60097PE.1 | 25 tests |
Anti-Hu CD45RO, UCHL1, FI, 100tests | 60097FI | 100 tests |
Anti-Hu CD45RO, UCHL1, FI, 25tests | 60097FI.1 | 25 tests |
Anti-Hu CD45RO, UCHL1, BT, 100µg | 60097BT | 100 µg |
Anti-Hu CD45RO, UCHL1, BT, 25µg | 60097BT.1 | 25 µg |
Anti-Hu CD45RO, UCHL1, AZ, 100tests | 60097AZ | 100 tests |
Anti-Hu CD45RO, UCHL1, AZ, 25tests | 60097AZ.1 | 25 tests |
Anti-Hu CD45RO, UCHL1, AD, 100tests | 60097AD | 100 tests |
Uante,您的科研物资战略合作伙伴！
重庆市寰宇安泰生物科技有限公司
