Stemcell 60018AZ.1 Anti-Human CD45 Antibody, Clone HI30
Product Overview
The HI30 antibody reacts with all isoforms of CD45, a type I transmembrane glycoprotein expressed on the surface of most hematopoietic cells except mature erythrocytes, platelets and plasma cells; expression of CD45 is lost during differentiation of these cell types. CD45 is a member of the protein tyrosine phosphatase family and functions in a number of immunoregulatory processes, including cell activation, growth, differentiation and oncogenic transformation. The large cytoplasmic portion of CD45 contains two tyrosine phosphatase domains, one which is enzymatically active, that are involved in modulating the function of intracellular substrates such as the Src kinases Lck and Fyn. Several isoforms of CD45 have been identified, the expression of which differs according to cell type and functional status. Alternative splicing of three exons (4, 5, 6) encoding the extracellular RA, RB and RC polypeptide sequences gives rise to up to 8 isoforms with molecular masses in the range of 180 - 240 kDa. The Leucocyte Common Antigen, the region recognized by the HI30 antibody, is an extracellular region located proximal to the membrane and common to all isoforms of CD45.
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051), EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052) and EasySep™ Human CD45 Depletion Kit (Catalog #18259; partial blocking may be observed).
Subtype:一抗
Target Antigen:CD45
Reactive Species:黑猩猩; 人
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP-Cyanine5.5; 未结合
Host Species:小鼠
Cell Type:粒细胞及其亚型; 造血干细胞和祖细胞; 淋巴细胞; 髓系细胞
Application:细胞分离; CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学
Clone:HI30
Gene ID:5788
Isotype:IgG1, kappa
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Anti-Hu CD45, HI30, PE | 60018PE | 100 tests |
Anti-Hu CD45, HI30, FI, 100tests | 60018FI | 100 tests |
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Anti-Hu CD45, HI30, BT, 100µg | 60018BT | 100 µg |
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Anti-Hu CD45, HI30, AZ, 100tests | 60018AZ | 100 tests |
Anti-Hu CD45, HI30, AZ, 25tests | 60018AZ.1 | 25 tests |
Anti-Hu CD45, HI30, AD, 25 | 60018AD.1 | 25 tests |
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Anti-Hu CD45, HI30 | 60018 | 100 µg |
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