Stemcell 60040AZ Anti-Human CD11b Antibody, Clone ICRF44
Product Overview
The ICRF44 antibody reacts with an extracellular epitope on CD11b (integrin αM), an ~170 kDa type 1 transmembrane glycoprotein which associates non-covalently with CD18 to form the heterodimeric Mac-1 receptor. Through its interactions with ligands such as ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, heparin and fibrinogen, Mac-1 influences several processes, including the adherence of neutrophils and monocytes to stimulated endothelium, and phagocytosis of complement-coated particles. CD11b is expressed on the surface of granulocytes, monocytes, NK cells, dendritic cells, tissue macrophages and subsets of T and B cells, and has been used as a marker to distinguish naïve and memory CD8+ T cells. CD11b is a relatively late marker for myeloid differentiation and is undetectable on most myelomonocytic hematopoietic progenitor cells and more primitive cells. Certain mutations in CD11b give rise to the disorder systemic lupus erythematosus. The ICRF44 antibody reportedly inhibits leukocyte aggregation in response to the chemoattractant fMLP.
This antibody clone has been verified for labeling human mesenchymal cells grown in MesenCult™ Proliferation Kit (Human; Catalog #05411) and MesenCult™-XF Medium (Catalog #05420).
Subtype:一抗
Target Antigen:CD11b
Reactive Species:狒狒; 黑猩猩; 普通狨猴; 食蟹猴; 人; 猪; 猕猴
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; 未结合
Host Species:小鼠
Cell Type:髓系细胞
Application:细胞分离; CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学
Clone:ICRF44
Gene ID:3684
Isotype:IgG1, kappa
Related products
Description | Catalog # | Format |
Anti-Hu CD11b, ICRF44, PE, 25 | 60040PE.1 | 25 tests |
Anti-Hu CD11b, ICRF44, PE | 60040PE | 100 tests |
Anti-Hu CD11b, ICRF44, FI, 100tests | 60040FI | 100 tests |
Anti-Hu CD11b, ICRF44, FI, 25tests | 60040FI.1 | 25 tests |
Anti-Hu CD11b, ICRF44, BT, 100µg | 60040BT | 100 µg |
Anti-Hu CD11b, ICRF44, BT, 25µg | 60040BT.1 | 25 µg |
Anti-Hu CD11b, ICRF44, AZ, 100tests | 60040AZ | 100 tests |
Anti-Hu CD11b, ICRF44, AZ, 25tests | 60040AZ.1 | 25 tests |
Anti-Hu CD11b, ICRF44, AD, 25 | 60040AD.1 | 25 tests |
Anti-Hu CD11b, ICRF44, AD | 60040AD | 100 tests |
Anti-Hu CD11b, ICRF44 | 60040 | 100 µg |
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