Anti-Human CD3 Antibody, Clone UCHT1
Product Overview
The UCHT1 antibody reacts with the ~20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NK-T cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin super family. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders including severe combined immunodeficiency disorder (SCID).
This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct Human T Cell Isolation Kit (Catalog #19661), EasySep™ Human CD3 Positive Selection Kit (Catalog #18051; partial blocking may be observed), EasySep™ HLA Whole Blood T Cell Enrichment Kit (Catalog #19951HLA) and EasySep™ HLA Whole Blood CD2 Positive Selection Kit (Catalog #18687HLA).
Subtype:一抗
Target Antigen:CD3
Reactive Species:黑猩猩; 人
Conjugation:Alexa Fluor 488; APC; 生物素; FITC; PE; PerCP; PerCP-Cyanine5.5; 未结合
Host Species:小鼠
Cell Type:T细胞
Application:细胞分离; CyTOF; 流式细胞术; 功能检测; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:免疫学
Clone:UCHT1
Gene ID:915
Isotype:IgG1, kappa
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Anti-Hu CD3, UCHT1, PE | 60011PE | 100 tests |
Anti-Hu CD3, UCHT1, FI, 100tests | 60011FI | 100 tests |
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Anti-Hu CD3, UCHT1, BT, 100µg | 60011BT | 100 µg |
Anti-Hu CD3, UCHT1, BT, 25µg | 60011BT.1 | 25 µg |
Anti-Hu CD3, UCHT1, AZ, 100tests | 60011AZ | 100 tests |
Anti-Hu CD3, UCHT1, AZ, 25tests | 60011AZ.1 | 25 tests |
Anti-Hu CD3, UCHT1, AD | 60011AD | 100 tests |
Anti-Hu CD3, UCHT1 | 60011 | 0.2 mL |
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