Anti-Human Beta-Tubulin III Antibody, Clone 2G10-TB3
Product Overview
The 2G10-TB3 antibody reacts with beta-tubulin III, an ~50 - 55 kDa structural protein that is a constituent of tubulin. Tubulin is the major component of microtubules within the cytoskeleton and is assembled from heterodimers of alpha and beta tubulin subunits. The beta III isoform of tubulin, also known as neuron-specific class III beta-tubulin, is expressed primarily in neurons and is widely used as a marker to distinguish neurons from other cell types. Beta-tubulin III contributes to microtubule formation in neuronal cell bodies and axons, a function involving GTP binding, and plays roles in axonal transport, neuronal cell proliferation, and differentiation. It is highly expressed in several types of cancer and is a predictive and prognostic marker for various tumors, for example, being found in neoplastic but not in normal glial cells. The 2G10-TB3 antibody is expected to recognize all mammalian homologs of beta-tubulin III and the epitope has reportedly been mapped to the extreme C-terminal amino acids, EAQGPK.
Subtype:一抗
Target Antigen:β-III微管蛋白
Reactive Species:人; 小鼠; 大鼠
Conjugation:未结合
Host Species:小鼠
Cell Type:PSC衍生神经细胞; 神经元
Application:流式细胞术; 免疫细胞化学; 免疫荧光; 免疫组化; 免疫沉淀; Western印迹法
Area of Interest:神经科学
Clone:2G10-TB3
Gene ID:10381
Isotype:IgG2a, kappa
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